Maternal infections during pregnancy and offspring midlife inflammation

Table 4 Associations between maternal infection and timing of maternal infection during pregnancy and inflammatory markers

		CRP		IL-6		IL-10		TNF-α
	Cases	Crude Factor (95% CI)	Factor (95% CI)*	Crude Factor (95% CI)	Factor (95% CI)*	Crude Factor (95% CI)	Factor (95% CI)*	Crude Factor (95% CI)	Factor (95% CI)*
Infection during pregnancy	392	0.93 (0.81,1.06)	0.93 (0.81,1.06)	0.92 (0.84,1.01)	0.92 (0.85,1.01)	0.91;(0.77,1.08)	0.91 (0.77,1.08)	0.99 (0.94,1.03)	0.99 (0.94,1.04)
Timing of infection
Never	1313	1	1	1	1	1	1	1	1
Trimester 1	55	1.04 (0.78,1.34)	1.05 (0.80,1.38)	0.88 (0.73,1.06)	0.90 (0.74,1.07)	0.95 (0.85,1.06)	0.95 (0.66,1.36)	0.95 (0.85,1.06)	0.95 (0.85,1.06)
Trimester 2 &/or 3 Trimester 1 & later in pregnancy	317 20	0.90 (0.78,1.02) 0.90 (0.78,1.02)	0.90 (0.79,1.03) 0.90 (0.78,1.02)	0.92 (0.84,1.02) 0.90 (0.78,1.02)	0.93 (0.84,1.02) 0.90 (0.78,1.02)	0.99 (0.94,1.04) 0.90 (0.78,1.02)	0.91 (0.76,1.09) 0.90 (0.78,1.02)	0.99 (0.94,1.04) 0.90 (0.78,1.02)	0.99 (0.94,1.04) 0.90 (0.78,1.02)

The factors and 95% confidence intervals (CI) are presented. Analyses based on 1719 men and women with continuous participation in the Copenhagen Perinatal Cohort and the Copenhagen Aging and Midlife Bioank
*Controlled for parity, maternal age, maternal pre-pregnancy BMI and smoking in the last trimester, maternal civil status, gender
BMI body mass index, CRP C-reactive protein, IL-6 Interleukin-6, IL-10 Interleukin-10, TNF-α tumor necrosis factor-α

ISSN: 2054-958X